When the Kingdom of Ruhuna was established it received many travellers and traders from Siam, China and Indonesia who sought anchorage in the natural harbor at Godawaya, Ambalantota. The ships or large boats these traders travelled in were called "Sampans" and thota means port or anchorage so the port where sampans anchor came to be known as Sampantota (which is now known as Godawaya). After some time the area came to be called Hambantota.[2]

Hambantota District is part of the traditional south known as Ruhuna. In ancient times this region, especially Hambantota and the neighboring areas was the centre of a flourishing civilization. Historical evidence reveals that the region in that era was blessed with fertile fields and a stupendous irrigation network. Hambantota was known by many names Mahagama, Ruhuna and Dolos dahas rata.

About 200 BC, the first Kingdom of Sri Lanka was flourishing in the north central region of Anuradhapura.

After a personal dispute with his brother, King Devanampiyatissa of Anuradhapura, King Mahanaga established the Kingdom of Ruhuna in the south of the island. This region played a vital role in building the nation as well as nurturing the Sri Lankan Buddhist culture. Close to Hambantota, the large temple of Tissamaharama was built to house a sacred tooth relic.[3]

Main articles: Colonial history of Sri Lanka and Sri Lanka in the twentieth century
Around the years of 1801 and 1803, the British built a Martello tower on the tip of the rocky headland alongside the lighthouse overlooking the sea at Hambantota. The builder was a Captain Goper, who built the tower on the site of an earlier Dutch earthen fort. The tower was restored in 1999, and in the past, formed part of an office of the Hambantota Kachcheri where the Land Registry branch was housed. Today it houses a fisheries museum.

From 2 August to 9 September 1803, an Ensign J. Prendergast of the regiment of Ceylon native infantry was in command of the British colony at Hambantota during a Kandian attack that he was able to repel with the assistance of the snow ship Minerva.[4] Earlier, HMS Wilhelmina had touched there and left off eight men from the Royal Artillery to reinforce him.[5] This detachment participated in Prendergast's successful defense of the colony.[6] If the tower at Hambantota was at all involved in repelling any attack this would be one of the only cases in which a British Martello tower had been involved in combat.

Leonard Woolf, future husband of Virginia Woolf, was the British colonial administrator at Hambantota between 1908 and 1911